Bacterial invasion of vascular cell types: vascular infectology and atherogenesis

The Difference of Expression of 18 Genes in Axillary Invasion and Vascular Invasion Compared to Control Samples in Breast Cancer

Background & Objective: Recent studies from gene profiling have revealed some genes that are overexpressed in the epithelial-mesenchymal transition (EMT) process and are responsible for its initiation and activation resulting in tumor progression and metastasis. The present study aimed to assess the role of genes involved in the EMT process and the association of these genes wi...

Applications of Cell Therapy in Vascular Surgery

Trying to use embryonic stem cells about 20 years ago, working with animals,  especially rats began. During these years , many experiments in mouse embryonic stem cells to transform into a variety of cells and transplanting them were led to remarkable success . In the next issue of human stem cells were considered successful until finally in 1998 the first report was published in the proliferat...

Atherogenesis and Vascular Disease in SLE

Commentary Vascular Endothelium, Hemodynamic Forces, and Atherogenesis

Intimal lipid accumulation, hyperplasia, and scarring are stigmata of atherosclerotic vascular disease, whose major complications—myocardial and cerebral ischemia and infarction—continue to be major health problems in developed nations. This insidiously progressive disease typically spans decades, but can reach a clinical horizon in a matter of minutes due to critical changes in a given atheros...

SM22 Modulates Vascular Smooth Muscle Cell Phenotype During Atherogenesis

The function of cytoskeletal proteins in the modulation of vascular smooth muscle cell (SMC) phenotype during vascular disease is poorly understood. In this report, we used a combination of gene targeting and Cre/loxmediated cell fate mapping in mice to investigate the role of SM22 , an SMC-specific cytoskeletal protein of unknown function, in the development of atherosclerosis. In hypercholest...